Invented by Shan Zhong, Benjamin Breton, Iain McFadyen, Kristen HOPSON, Vincent Luczkow, Maija Garnaas, ModernaTx Inc

Cancer is a disease that affects millions of people worldwide. It is a complex disease that can be caused by a variety of factors, including genetics, lifestyle, and environmental factors. One of the most promising areas of cancer research is the development of personalized cancer vaccines. These vaccines are designed to target the specific mutations and proteins that are unique to an individual’s cancer cells. This approach has the potential to be more effective than traditional cancer treatments, which often have significant side effects and may not be effective for all patients.

The market for personalized cancer vaccine epitope selection is growing rapidly. Epitopes are the specific parts of a protein that are recognized by the immune system. By selecting the right epitopes, researchers can design vaccines that are more effective at targeting cancer cells. The market for epitope selection services is expected to reach $1.2 billion by 2025, according to a report by MarketsandMarkets.

There are several factors driving the growth of the personalized cancer vaccine market. One of the main drivers is the increasing prevalence of cancer. As the population ages and lifestyles become more sedentary, the incidence of cancer is expected to continue to rise. This has led to increased investment in cancer research and the development of new treatments.

Another factor driving the market is the increasing availability of genomic data. Advances in technology have made it easier and more affordable to sequence the DNA of cancer cells. This data can be used to identify the specific mutations and proteins that are unique to an individual’s cancer cells. This information can then be used to design personalized cancer vaccines that are more effective at targeting the cancer cells.

The market for personalized cancer vaccines is also being driven by the increasing focus on precision medicine. Precision medicine is an approach to healthcare that takes into account an individual’s unique genetic makeup, lifestyle, and environment. By tailoring treatments to the individual, precision medicine has the potential to be more effective and have fewer side effects than traditional treatments.

There are several companies that are leading the way in the personalized cancer vaccine market. These companies offer a range of services, from sequencing and analysis of genomic data to the design and production of personalized cancer vaccines. Some of the leading companies in the market include Genocea Biosciences, Gritstone Oncology, and Neon Therapeutics.

In conclusion, the market for personalized cancer vaccine epitope selection is growing rapidly. Advances in technology and the increasing prevalence of cancer are driving the demand for personalized cancer vaccines. As the market continues to grow, we can expect to see more companies entering the market and more innovative treatments being developed. The future of cancer treatment is personalized, and the personalized cancer vaccine market is at the forefront of this exciting new field.

The ModernaTx Inc invention works as follows

The disclosure is a description of optimized cancer vaccines as well as methods for making, using, and composing vaccines. Cancer vaccines are made up of personalized cancer antigens, or portions from cancer hotspots antigens. The disclosure also relates to an automated system for selecting nucleic acid to include in a cancer optimized vaccine.

Background for Personalized cancer vaccine epitope selection

Peptide Epitopes

Personalized Cancer Vaccines

Methods of Preparation

Hotspot mutations as Neoantigens

Nucleic Acids/Polynucleotides

Antigens/Antigenic Polypeptides

Chemical Modifications

Modified Nucleotide Sequences Encoding Epitope Antigen Polypeptides

Untranslated regions (UTRs),

3? “3?

Regions with a Cap of 5?” Cap

Poly-A Tails

Start Codon Region

Stop Codon Region

Insertions & Substitutions

Computerized Systems

Methods of Treatment.

Formulations

Kits

EXAMPLES

Example 1. “Manufacture of polynucleotides”.

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